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The Whites, who scored more than 100 points for the second game in a row, set their sights on victory over San Pablo Burgos in the first half. Thompkins recorded his best performance for the Whites (27 points and 30 PIR).
Real Madrid beat Valencia Basket at home to complete the best run of any team in this year's competition.
The Whites suffer the lack of accuracy in a match dominated by the home team.
The away win against Zenit means a sixth consecutive win in Europe.
The league leaders record their third win in the week and their ninth victory in this competition.
A spectacular game from the Argentine, his best for the Whites, secured a second victory win for Laso's side in three days.
Real Madrid put the contest to bed after scoring 65 points before the break. Six players ended the game with double digit PIRs.
The Whites had two possessions to win the game, at the end of the 40 minutes and in overtime.
The Whites took the second Clásico of the season as well at an impenetrable WiZink Center.
Eighth consecutive victory for the leaders, who remains undefeated in this competition with a great performance from Tavares and Deck.
Real Madrid
Athletic
Olimpia Milán 
