Lopetegui has used 19 outfield players

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Reguilón was the latest member of the squad to play this term with his performance in Moscow.
After 11 official matches - the European Super Cup, eight LaLiga games and two in the Champions League - Lopetegui has already used 19 outfield players, along with Keylor Navas and Courtois, who have also played in the opening stages of this campaign.
 
The last to join this list is Sergio Reguilón, who made his first team debut in Moscow, playing the 90 minutes against CSKA. Two other madridistas have made their debuts this season, Odriozola, started in the win over Espanyol, and Vinicius, who came on in the second half against Atlético.
 
Most minutes
As for the players most used by Lopetegui, Sergio Ramos leads the way. The captain has taken part in ten matches at the start of the campaign, completing 930 minutes and placing himself ahead of Kroos (912), Benzema (884) and Varane (870).